Editorial on PEGASUS-TIMI 54

Implications of the PEGASUS-TIMI 54 trial for US clinical practice

OBJECTIVES This study aims to determine the proportion of real-world patients with myocardial infarction (MI) who would have been eligible for the PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, to characterise their current use of P2Y12 inhib...

Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54.

AIMS Ticagrelor reduced major adverse cardiovascular event (MACE) by 15-16% in patients with prior myocardial infarction (MI) in PEGASUS-TIMI 54. We hypothesized that patients who recently discontinued P2Y12 inhibition, even years after MI, may be at particular risk of MACE and may derive particular benefit from continuation or reinitiation of therapy. METHODS AND RESULTS Patients in PEGASUS-...

Efficacy and safety of ticagrelor for long-term secondary prevention of atherothrombotic events in relation to renal function: insights from the PEGASUS-TIMI 54 trial.

AIMS We evaluated the relationship of renal function and ischaemic and bleeding risk as well as the efficacy and safety of ticagrelor in stable patients with prior myocardial infarction (MI). METHODS AND RESULTS Patients with a history of MI 1-3 years prior from PEGASUS-TIMI 54 were stratified based on estimated glomerular filtration rate (eGFR), with <60 mL/min/1.73 m(2) pre-specified for an...

Prevention of stroke with ticagrelor in Patients with Prior Myocardial infarction insights from PegasUs-tiMi 54 (Prevention of cardiovascular events in Patients With Prior heart attack Using ticagrelor compared to Placebo on a Background of aspirin-thrombolysis in Myocardial infarction

861 Marc P. Bonaca, MD, MPH Shinya Goto, MD Deepak L. Bhatt, MD, MPH P. Gabriel Steg, MD Robert F. Storey, MD Marc Cohen, MD Erica Goodrich, MS Laura Mauri, MD Ton Oude Ophuis, MD, PhD Mikhail Ruda, MD Jindřich Špinar, MD Ki-Bae Seung, MD Dayi Hu, MD Anthony J. Dalby, MD Eva Jensen, MD, PhD Peter Held, MD, PhD David A. Morrow, MD, MPH Eugene Braunwald, MD Marc S. Sabatine, MD, MPH Original rese...

Remarks on the Pegasus Cluster of Nebulae.